It all depends on the quality. You can get really poorly drawn comics with little to no story at all and have sprite comics with deep and rich story with real backgrounds (that can also be photoshopped to create more exotic environments), lighting effects, shadows, highlights, reflections, glowing effects, etc. added to the sprites.
However, there are also very cheaply made sprite comics with no coherency whatsoever and hand-drawn comics that are beautifully detailed with intriguing plots and amazing use of techniques like perspective and crosshatching that just blow everyone away.
Saying one is better than another is stupid.
|—||From Emkay-MLP, in response to a bit of loldrama going on in BZPower about whether Hand-Drawn Comics or Sprite Comics are better. Truer words on this subject have never been spoken.|